Cancer Clinical Trial Resources

QuickLink: Colorectal Cancer Trial Information

17,500 Participants Needed to Enroll in Major Colorectal Cancer Clinical Trials

Recently a group of experts from the oncology research community, academia, cancer cooperative groups, patient advocacy, and industry identified trials as high priority colorectal cancer clinical studies that address important research opportunities and merit support for rapid completion. Combined, these ten large studies require more than 17,500 participants.

The Coalition's Scientific Leadership Council in Gastrointestinal (GI) Cancer presented these trials as part of their recommendations for the future direction of colorectal cancer research at a forum in Washington DC in December 2005 and at a major GI cancer meeting in San Francisco in January 2006.

Following is a list of these ten priority colorectal cancer clinical trials. Click here to determine if you are eligible for these and other cancer treatment trials. Contact Kelly Glacken at 215-399-0424 or kglacken@CancerTrialsHelp.org if you have any questions.

Screening and Prevention

Early-stage Colon Cancer (Combined With Surgery)

Protocol ID: ECOG-E5202
Protocol Title: Phase III Randomized Study of Oxaliplatin, Leucovorin Calcium, and Fluorouracil With Versus Without Bevacizumab in Patients With Resected Stage II Colon Cancer
View Trial Summary and Locations Where This Study Is Available

Protocol ID: NCCTG-N0147
Protocol Title: A Randomized Phase lll Trail of Oxaliplatin (OXAL) Plus 5-Fluorouracil (5-FU)/Leucovorin (CF) With or Without Cetuximab (C225) After
Curative Resection for Patients With Stage lll Colon Cancer
View Trial Summary and Locations Where This Study Is Available

Early-stage Rectal Cancer (Combined With Surgery)

Protocol ID: E5204
Protocol Title: Phase III Study of Postoperative Oxaliplatin, 5-Fluorouracil and Leucovorin vs Oxaliplatin, 5-Fluorouracil, Leucovorin and Bevacizumab for Patients With Stage II or III Rectal Cancer Receiving Pre-operative Chemoradiation
View Trial Summary and Locations Where This Study Is Available

Protocol ID: NSABP-R-04
Protocol Title: Randomized Study of Preoperative Chemoradiotherapy Comprising Radiation Therapy and Either Capecitabine or Fluorouracil With or Without Oxaliplatin in Patients With Resectable Rectal Cancer
View Trial Summary and Locations Where This Study Is Available

Advanced Colorectal Cancer (Colorectal Cancer That has Spread to Other Organs)

Protocol ID: N014A
Protocol Title: Phase II Study of Oxaliplatin, Fluorouracil, Leucovorin Calcium, and Cetuximab in Patients With Unresectable Hepatic Metastases Secondary to Metastatic Colorectal Adenocarcinoma
View Trial Summary and Locations Where This Study Is Available

Protocol ID: C80405
Protocol Title: A Phase III Trial of Irinotecan/5-FU/Leucovorin or Oxaliplatin/5-FU/Leucovorin With Bevacizumab, or Cetuximab (C225), or With the Combination of Bevacizumab and Cetuximab for Patients With Untreated Metastatic Adenocarcinoma of the Colon or Rectum
View Trial Summary and Locations Where This Study Is Available

Protocol ID: NSABP-C-09
Protocol Title: Phase III Randomized Study of Adjuvant Therapy Comprising Oxaliplatin and Capecitabine With Versus Without Hepatic Arterial Infusion of Floxuridine in Patients Undergoing Surgical Resection and/or Ablation for Hepatic Metastases From Colorectal Cancer
View Trial Summary and Locations Where This Study Is Available

Protocol ID: ECOG-E4203
Protocol Title: Phase II Study of Treatment Selection Based Upon Tumor Thymidylate Synthase Expression in Previously Untreated Patients With Metastatic Colorectal Cancer
View Trial Summary and Locations Where This Study Is Available